Small Molecule Metabolites in Drug Discovery and Development
An ISSX Virtual Workshop Event | March 1-3, 2023
Workshop Overview
This workshop is organized through the efforts of the ISSX Biotransformation Mechanisms and Pathways Focus Group and is chaired by Carley Heck of Pfizer and Valerie Kramlinger of Vanderbilt University.
This virtual workshop focused on the impact of small organic molecule metabolism science on both drug discovery and drug development. This three day workshop reviewed the types of in vitro and in vivo drug metabolism studies conducted to support the drug discovery-development pipeline, including the experimental and analytical techniques used and the impact of the data generated. Some of the exciting topics covered were: the importance of drug metabolites, analytical techniques of metabolite ID, prediction of human circulating metabolite profiles, metabolite biosynthesis, human ADME study strategies and impact, and both the pharmaceutical industry and regulatory perspectives on the value of human ADME studies and drug metabolism science. Each session of this workshop featured 4-5 expert speakers, a daily panel discussion, and poster sessions selected from the pool of abstracts from the students and industry attendees.
The workshop includes access to all presentation slides and recordings.
