Tuesday, September 17, 2024
Program subject to change.
7:15 am - 8:15 am | Concurrent Industry-Sponsored Symposia
8:30 am - 9:30 am | Keynote Lecture 2
In Vitro - In Vivo Extrapolation Approaches for Glucuronidated Drugs: Promises and Pitfalls
John O. Miners, Flinders University, Adelaide, Australia
9:30 am - 10:00 am | Refreshment Break with Posters and Exhibitors
10:00 am - 12:00 pm | Concurrent Symposia 5 and 6
Symposium 5: Alternatives to Animal Models/3Rs – Based on the Recent Legislation for New Medicines Not Necessarily Requiring Testing in Animals
Co-Chairs: Seiichi Ishida, Sojo University, Kumamoto, Japan and Diane Ramsden, AstraZeneca, Waltham, Massachusetts, USA
Regulatory Acceptance of MPS - Consideration from Context of Use
Seiichi Ishida, Sojo University, Kumamoto, Japan
Prediction of Drug Intestinal Absorption and Toxicity with the Use of Human/Animal Crypt-derived Cultured Intestinal Cells
Kazyua Maeda, Kitasato University, Tokyo, Japan
Rat and Dog Quad-culture Liver Chip Models: Characterization and Use to Interrogate a Potential Flavin-containing Monooxygenase-mediated, Species-specific Toxicity of a Histamine Receptor Antagonist
David Stresser, Abbvie, North Chicago, Illinois, USA
In Vitro Evaluation Methods for Hepatic and Renal Drug Disposition and Toxicity
Ikumi Tamai, Kanazawa University, Kanazawa, Japan
Symposium 6: Current Status, Challenges and Opportunities for Phenotyping of Low Clearance Compounds - (IQ TALG Organized Session)
Co-Chairs: Takafumi Komori, Eisai, Tokyo, Japan and Sarah Glass, Janssen, San Diego, California, USA
Update from the IQ TALG Quantitative Fraction Metabolized Working Group
Angela Doran, Pfizer, Groton, Connecticut, USA
Phenotyping Assay Using Genetically Manipulated Human iPS Cell-derived Hepatocyte-like Cells
Hiroyuki Mizuguchi, Osaka University, Suita, Japan
Advances in Enabling IVIVE and Enzyme Phenotyping of Low Clearance Compounds
Mitesh Patel, Novartis, Cambridge, Massachusetts, USA
Evaluation of Low CL Compounds Using Chimeric Mice with Humanized Liver
Hiroshi Suemizu, Central Institute for Experimental Medicine and Li, Kawasaki, Japan
12:00 pm - 2:30 pm | Lunch, Exhibits, and Poster Presentations
12:00 pm -12:30 pm | Lunch, Exhibit Hall Hours, and Poster Viewing
12:30 pm - 1:30 pm | Odd-numbered Poster Presentation Session
1:30 pm - 2:30 | Even-numbered Poster Presentation Session