Wednesday, September 18, 2023
Program subject to change.
7:15 am - 8:15 am | Concurrent Industry-Sponsored Symposia
8:30 am - 9:30 am | Plenary Lecture 2
Species Specificity and Selection of Animal Models for Drug Oxygenations Differently Contributed by Polymorphic Human Enzymes
Hiroshi Yamazaki, Showa Pharmaceutical University, Machida, Japan
9:30 am - 10:00 am | Break with Posters and Exhibitors
10:00 am - 12:00 pm | Concurrent Symposia 7 and 8
Symposium 7: Solving ADME/Tox Challenges in Drug Discovery
Co-Chairs: Hideki Hirabayashi, Takeda, Japan and Deepak Dalvie, Crinetics, San Diego, California, USA
Discovery of PF-07817883, a Second-Generation Oral SARS-CoV2 Main Protease Inhibitor
Amit Kalgutkar, Pfizer, Cambridge, Massachusetts, USA
Uncovering Target-Mediated Drug Disposition (TMDD) of Small Molecule Brain Penetrant EBP Inhibitors
Laurent Salphati, Genentech, South San Francisco, California, USA
A Tale of Preclinical Insights into Bile Salt Homeostasis Disruption in DILI
Yurong Lai, Gilead, Dublin, California, USA
Best Practice of Mitigating P-glycoprotein Liabilities in Drug Discovery - Assessment and Prediction of P-gp Mediated Nonlinear PK, Brain Penetration, and Interactions
Hideki Hirabayashi, Takeda, Fujisawa, Japan
Symposium 8: Manage Drug Disposition and Toxicity in Specific Population: From Mechanistic Understanding to PBPK Modelling
Co-Chairs: Masayo Oishi, Astellas, Tsukuba-shi, Japan and Xiaoyan Chu, Merck, Rahway, New Jersey, USA
Unraveling Cannabinoids-drug Interactions in Aging: Insights from PBPK Modeling
Zhu Zhou, City University of New York, Jamaica, New York, USA
Model-based Meta-analysis of Ethnic Differences - General Changes in Clearance by Pathways and Aging
Akihiro Hisaka, Chiba University, Chiba, Japan
Mechanisms Underlying Altered Drug Clearance in Pregnancy
Muluneh Fashe, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
Alteration of Blood Brain-barrier Proteome in Various Conditions
Sumio Ohtsuki, Kumamoto University, Kumamoto, Japan
12:00 pm - 2:30 pm | Lunch, Exhibits, and Poster Viewing
12:00 pm -12:30 pm | Lunch, Exhibit Hall Hours, and Poster Viewing
12:30 pm - 1:30 pm | Odd-numbered Poster Presentation Session
1:30 pm - 2:30 | Even-numbered Poster Presentation Session
2:30 pm - 4:30 pm | Plenary Session
Digging Into the Complexities of Natural Products with Integrative Tools to Improve Pharmacotherapy
Co-Chairs: Mary Paine, Washington State University, Spokane, Washington, USA and Huichang (Nancy) Bi, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
Authenticity and Adulteration of Botanical Natural Products: Lessons from a Decade of Sourcing Materials for Scientific Investigation
Nadja Cech, University of North Carolina Greensboro, Greensboro, North Carolina, USA
Schisandra Sphenanthera : Its Hepatoprotection and Beyond
Huichang Bi, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
Botanical-Drug Interactions: Blazing the Trail Using Translational Tools
Mary Paine, College of Pharmacy & Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA
Challenges and Breakthroughs in the Conduct of Clinical Cannabis Studies
Ryan Vandrey, Johns Hopkins University, Baltimore, Maryland, USA
Developing Natural Products as Potential Therapeutic Agents
Amala Soumyanath, Oregon Health & Science University, Portland, Oregon, USA
4:30 pm - 5:00 pm | Closing Session
Closing Remarks