Monday, September 11, 2023
Program subject to change.
7:00 am - 8:15 am | New Investigators Networking Session | Commonwealth Ballroom
All investigators within their first ten years of receiving their highest earned degree are welcome to attend and participate in this session. The forum, hosted by the ISSX New Investigators Group, begins with continental breakfast, followed by round table discussions lead by researchers in academia, industry, and government.
8:30 am - 9:30 am | Plenary Lecture 1 | Grand AB
Systematic Investigation of the Metabolism of Cannabinoids by Human Cytochrome P450s
Aditi Das, Georgia Institute of Technology, Atlanta, Georgia, USA
9:30 am - 10:00 am | Refreshment Break with Posters and Exhibitors | Galleria Hall
9:45-10:00 am | Exhibitor Showcase by Admescope
In vitro – in vivo Correlation of Antisense Oligonucleotide Metabolism
Dr. Ari Tolonen, CSO & Head of in vitro Metabolism and Biotransformations
10:00 am - 12:00 pm | Concurrent Symposia 1 and 2
Symposium 1: Quantitative LC-MS Proteomics | Grand AB
Chairs: Amin Rostami, University of Manchester, Manchester, United Kingdom and Bhagwat Prasad, Washington State University, Pullman, Washington, USA
What is New in LC-MS Proteomics: Techniques and Applications in IVIVE and Precision Medicine
Bhagwat Prasad, Washington State University, Spokane, Washington, USA
This is No Longer Just about Liver: LC-MS Proteomics for Organ Exposure Brain/Kidney/Gut/Skin/Placenta
Zubida Al-Majdoub, University of Manchester, Manchester, United Kingdom
LC-MS for Identifying Changes (or lack of it) in ADME Across Different Cohorts
Christine Wegler, Uppsala University, Umea, Sweden
From Stratified Dose Adjustment to Personalised Dosing: Linking LCMS Proteomics in Tissues to More Clinically Practical Liquid Biopsy Samples – Opportunities and Challenges
Brahim Achour, the University of Rhode Island, Kingston, Rhode Island, USA
Symposium 2: ADME of RNA-based Therapeutics | Marina Ballroom
Chairs: Julie Lade, Amgen, Baltimore, Maryland, USA and Viva Ayyar, Janssen R&D, Spring House, Pennsylvania, USA
One Size Does Not Fit All: Preclinical Tools to Characterize the Pharmacokinetics and Biodistribution of GalNAc-siRNA
Julie Lade, Amgen, Baltimore, Maryland, USA
Mechanistic Pharmacokinetics & Pharmacodynamics of GaINAc-siRNA
Viva Ayyar, Janssen R&D, Pennsylvania, USA
Designing Novel RNA Medicines for the Brain
Julia Alterman, University of Massachusetts, Boston, Massachusetts, USA
Endosomal Escape for Intracellular Delivery of RNA Therapeutics: Current and Future Strategies
Chris MacLauchlin, Alnylam, Raleigh, North Carolina, USA
12:00 pm - 3:00 pm | Exhibits and Posters | Galleria Hall
Exhibit Hall Open with Concessions Available
12:15-12:45 pm | Exhibitor Showcase by SOLVO, a Charles River Company
Solving Major Pitfalls of MDR1 Species Differences and MDR1/MDR3 Substrate Specificity Overlap with Novel in vitro Monolayer Systems
Marko Andric, Senior Business Development, DMPK, Charles River
2:15-2:45 pm | Exhibitor Showcase by Discovery Life Sciences
Gentest® in vitro Preclinical Solutions at Discovery
David Randle, PhD, VP, Preclinical Services, Discovery Life Sciences
Poster Awards Competition Finalist Poster Presentations Posters A1-A12
Poster Viewing
3:00 pm - 5:00 pm | Concurrent Symposia 3 and 4
Symposium 3: Pediatrics | Grand AB
Chair: Amin Rostami, University of Manchester, Manchester, United Kingdom and Steven Leeder, Children's Mercy, Kansas City, Missouri, USA
Challenges and Opportunities of Modeling and Simulation in Pediatrics: Adults are Just Big Children
Steven Leeder, Children's Mercy, Kansas City, Missouri, USA
Story of Maturation - Modelers vs Models in the Paediatric Space
Amin Rostami, University of Manchester, Manchester, United Kingdom
Modern Pediatric Drug Development: Practical Case Examples and Regulatory Outcomes from Novel Applications of Modelling
Michael Gertz, F. Hoffman La Roche, Ltd., Basel, Switzerland
Practical Use of Mechanistic Modeling to Discern Real Word Complex Drug Interactions
Joseph Grillo, US Food and Drug Administration, Silver Spring, Maryland, USA
Symposium 4: Strategies to Deliver Biologics to the Site of Action | Marina Ballroom
Chairs: Isabel Figueroa, Amgen, Inc., Waltham, Massachusetts, USA
An in vitro Microphysiological Model of Subcutaneous Delivery
Roger Kamm, Massachusetts, Institute of Technology, Cambridge, Massachusetts, USA
Opportunities and Challenges in Drug Development for Retinal Diseases
Paulina Jakubiak, Genentech, South San Francisco, California, USA
Mathematical Modeling of Affinity Design Goals for Cis-binding Bi-specific Antibody-based Molecules
Isabel Figueroa, Amgen, Inc., South San Francisco, California, USA
Anchored Intratumoral Cytokine Immunotherapy
Dane Wittrup, Massachusetts Institute of Technology, Cambridge, Massachusetts
5:00 pm - 5:30 pm | Refreshment Break with Posters and Exhibitors | Galleria Hall
5:30 pm - 6:30 pm | ISSX North American Awards Presentations | Grand AB
ISSX North American Scientific Achievement Award Presentation and Lecture
To be presented to Jashvant Unadkat, Ph.D., Professor at the School of Pharmacy, University of Washington, Seattle, Washington, USA
ISSX Distinguished Accomplishments in Drug Discovery and Development Award
To be presented to the Pfizer Paxlovid Team
