Small Molecule Metabolites in Drug Discovery and Development
An ISSX Virtual Workshop Event | March 1-3, 2023
Workshop Program-at-a-Glance
Wednesday, March 1, 2023 | 10:00 am - 3:30 pm ET (US)
Session 1
10:00 am - 10:05 am | Welcome and Introduction
10:05 am - 10:45 am | Why Drug Metabolites Can be Important; Examples of Active and Toxic Metabolites
Rheem Totah, University of Washington, Seattle, Washington, USA
10:45 am - 11:30 am | Modern Method of Metabolite ID: Part 1. HRMS: Instrumentation, Strategies
Mark Cancilla, Merck & Co., Inc, West Point, Pennsylvania, USA
11:30 am - 11:45 am | Break
11:45 am - 12:30 pm | Modern Method of Metabolite ID: Part 2. 1D and 2D NMR
Gregory Walker, Pfizer, Groton, Connecticut, USA
12:30 pm - 1:15 pm | Predicting Human Metabolites from Pre-clinical Information and Models – Qualitative and Quantitative
Ernie Callegari, Pfizer, Groton, Connecticut, USA
1:15 pm - 2:00 pm | Accessing Metabolites of Various Types – Biosynthesis, Isolation Methods
Liz Gillam, University of Queensland
2:00 pm - 2:30 pm | Break
2:30 pm - 3:30 pm | Roundtable Discussion with Speakers
Thursday, March 2, 2023 | 10:00 am - 3:30 pm ET (US)
Session 2
10:00 am - 10:05 am | Welcome and Introduction
10:05 am - 10:45 am | The human ADME study: Comparison of Various Strategies and Technical Approaches
Chandra Prakash, Agios, Cambridge, Massachusetts, USA
10:45 am - 11:30 am | Technical Aspects of AMS – Deep Dive on How AMS Actually Works
Stefan Blech and Ralf Laux, Boehringer Ingelheim, Biberach, Germany
11:30 am - 11:45 am | Break
11:45 am - 12:30 pm | How to Deal with Metabolites from Human ADME: Part 1. MIST
Yuexia Liang, Merck & Co., West Point, Pennsylvania, USA
12:30 pm - 1:15 pm | How to Deal with Metabolites from Human ADME: Part 2. Target Activity, DDI, and Modelling Impact Relative to Parent Drug
Sheila Peters, Boehringer Ingelheim, Biberach, Germany
1:15 pm - 2:00 pm | Roundtable Discussion with Speakers
2:00 pm - 2:30 pm | Break
2:30 pm - 3:30 pm | Poster Session 1
Friday, March 3, 2023 | 10:00 am - 3:30 pm ET (US)
Session 3
10:00 am - 10:05 am | Welcome and Introduction
10:05 am - 10:45 am | Industry Perspective on the Value of ADME Studies and Drug Metabolites
Douglas Spracklin, Pfizer, Groton, Connecticut, USA
10:45 am - 11:30 am | Drug Metabolites and Their Roles in Drug-drug Interactions
Xinning Yang, US FDA, Silver Spring, Maryland, USA
11:30 am - 11:45 am | Break
11:45 am - 12:30 pm | Vignette 1
Simone Schadt and Kenichi Umehara, F. Hoffmann-La Roche Ltd., Basel Switzerland
12:30 pm - 1:15 pm | Vignette 2
Sekhar Surapaneni, BMS
1:15 pm - 1:55 pm | Roundtable Discussion with Speakers
1:55 pm - 2:00 pm | Closing Remarks
2:00 pm - 2:30 pm | Break
2:30 pm - 3:30 pm | Poster Session 2
